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Puno is a city in southeastern Peru, located at the edge of Lake Titicaca, the world's highest navigable lake, at 3860 m (12421 ft) above sea level. It is also the capital and largest city of the Puno region and the Puno province.

Before the expansion of the Inca Empire, present-day Puno, in the southernmost part of Peru, was home to the Tiwanaku culture, the apex of Aymara human development, as shown by archaeological remains discovered in the area.

Puno is also believed to have been the cradle of the Inca civilization, as legend has it that Manco Capac, the first Inca, rose from the waters of Lake Titicaca, under the orders of the Sun God, to found the Inca Empire.

Source: http://en.wikipedia.org/wiki/Puno