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Great American Ball Park is the home of the National League's Cincinnati Reds. The park opened on March 28, 2003 with an exhibition game with the Cleveland Indians. The first regular season game, on March 31, 2003, saw the visiting Pittsburgh Pirates defeat the Reds 10-1. The ceremonial first pitch was thrown by former President George H. W. Bush, who replaced his son, current president George W. Bush, who was scheduled, but unable to attend. The younger Bush eventually did get the opportunity to throw out the first pitch before the Reds' April 4, 2006 opening day game versus the Chicago Cubs.

Contrary to popular belief, the park's name is not a patriotic reference. Consistent with the norm in American professional sports, Great American Ball Park is named after a business sponsor, the Great American Insurance Group. Great American is the insurance division of American Financial Group, Inc., the principal shareholder of which is former Cincinnati Reds majority owner Carl Lindner, Jr.